Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. Those days are gone. The evidence is solid. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Perhaps Kirschs most effective tactic, though, is simply his willingness to outlast everyone else. I must admit that this is an anniversary that snuck Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. We could have saved a lot of lives. If you cant lay off the java, then try fluoxetine (Prozac). Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. Most recent articles first. sorry about that. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. Were having trouble saving your preferences. Reason is the hospital gets release from liability if they follow NIH guidelines. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. I couldn't agree more. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. saying that the per-protocol analysis was arbitrary and other excuses. He has been a medical philanthropist for more than 20 years. . Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Completely avoid caffeine, alcohol, tylenol, and benadryl. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. Its motivated out of his sense of keeping people safe and advancing health care.. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. Refresh. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. The babys brain was split in half, and it was just covered with blood. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 Your best bet is to. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. I was just getting tired, he said, before asking to speak off the record. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. Timing is everything with respect to outcomes. The Wall Street Journal thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). Online. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. This story is part of the Pandemic Technology Project, supported by The Rockefeller Foundation. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Hilary Grant-Valdez Operations Manager Tom Brunner including the very promising Fluvoxamine. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. (Siliciano did not respond to requests for comment for this article.). Last Checked: 03/02/2023. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. The documents in the data room discuss all eight (you'll need access to the restricted area to see the presentation on all 8). There are other non-prescription things you should always have on hand. But they dont want their names used. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. How covid-19 conspiracy videos keep getting millions of views. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. Long haul. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. [NIH] doesnt want any of these treatments. Its all about NIH saying it is OK. . The results would, eventually, set Kirsch on a collision course with the scientific establishment. The incident, he added, was completely in keeping with his personality.. Medicine today isnt about saving your life. It never was. He retired at the largest pension in federal history. In some cases, youd want to taper down the dosage. As of November 13, fluvoxamine has been proven to work in every trial that has published results, including outpatient and inpatient studies. The medical community doesnt care about saving lives. It doesnt get any better than this. Author Affiliations Article Information. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Some are views most scientists think are wrong. Physicians who use the drug for COVID now swear by it. So probability of successful Phase 3 can be estimated to be over 99.99% since there are tens of thousands of phase 3 studies. This document is a collection of evidence that highlights the glaring errors in our pandemic response. The infectious disease scientists lied to me. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. In fact, he was unwittingly the source for one of Kirschs figures. Compulsive hand washing? Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. But the confusion provided a fertile breeding ground for skeptics. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. My favorite dosage is 50mg twice a day for 14 days. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. But even that didnt last long. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Proven in clinical use all over the world. This is the gold standard of evidence based medicine. Their willingness to lie did. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. Here are my answers. The CDC has advised everyone to wear a mask. It cant be more clear than this. . Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. I will . I wanted to get the article out before my flight left. Get your prescription in advance of getting COVID. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. This alone will give roughly a 50% effect size and explains why all of the the SSRIs are effective including those that do not activate the Sigma1 receptor (e.g., Paroxetine). of the 'intellectual dark web '" and allowed him to access a "large and receptive audience to his claims about a fluvoxamine conspiracy". The claim that the spike is toxic, that came directly from the [DarkHorse episode]. You can use fluoxetine as well (aka Prozac). By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. I have never heard of a case it didn't work. This is why Cliff doesnt talk to me. It was completed in August. A very short op-ed arguing for using fluvoxamine against COVID. Mouse Systems is not a household word, he told the journalist. Food/drugs to avoid while on fluvoxamine. We have a bounty of vaccines and more on the way, but drugs that treat the disease are vital too if we want to keep people alive and bring the pandemic under control. Note that some of these articles are inaccurate. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. All have had a 100% success record in keeping their patients out of the hospital. This is what the Seftel trial at Golden Gate fields used. The drug was FDA-approved more than 65 years ago. He may not be a good scientist, but hes smart, says WVUs Feinberg. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. This give another 50% of benefit. The choice couldn't be more clear cut. This advice is now outdated. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. Kirsch, despite having direct access to the actual trial runner, eventually became convinced a correct interpretation of the data would show that hydroxychloroquine worked. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. 4000fluvoxamine750 The reason that it isnt used is because the medical community ignores evidence-based medicine principles. There are 4 outpatient studies that have been done (2 at WashU (see. 1991-1992 to 7.1% in 2001-2002. Silence from the medical community. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. Fluoxetine is just as effective. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. It is perhaps the greatest unnecessary loss of life in American history. The web value rate of skirsch.io is 2 . This site requires JavaScript to run correctly. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. It doesnt get much better than that. The. 1. I think so. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. People are dying. Most recent articles first. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Do they sell it anywhere? He said of his study, This is the most extraordinary effect Ive seen in my 25 years practicing medicine.. That receptor also helps regulate the body's . This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. . Soon after his appearance on the DarkHorse podcast, several partners of his most recent startup, M10, expressed concerns about the increasing extremism of Kirschs vaccine views. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . . Waiting months for the phase 3 trial to complete is nuts. Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. If you start later, doctors use higher dosages and compliance becomes a bigger problem. has tons of info on fluvoxamine with all the links. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. Twenty-four years ago, . My crime? Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. He was recently featured on 60 Minutes, . On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. Completely avoid caffeine, alcohol, tylenol, and benadryl. Those who know Kirsch say this is a typical tactic. Thats why they didnt even fund the fluvoxamine trial, he told me. Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19). And not zero., Kirsch immediately forwarded the exchange to me and, I suspect, other journalists. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. Online. MisinformationKills. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Some people report mild nausea while on the drug (stops when stop the drug). May 16, 2022. See this Wall Street Journal op-ed. What has alarmed many of the scientists associated with CETF, though, are Kirschs reactions to the work hes fundedboth successes and failures. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. Sage Hana. Here is the latest version. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. Reason is the hospital gets release from liability if they follow NIH guidelines. This looks ominous, but it harmless. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Kirsch: Yes, but you could easily watch that 60 Minutes story and believe that we need more data before people should start using fluvoxamine. I took it myself at that dosage and noticed zero side effects. Steve Kirsch's Newsletter ^ | 02/26/22 | Steve Kirsch. more time. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. Why the FDA should grant an EUA for fluvoxamine immediately, a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients. My website www.skirsch.io has tons of info on fluvoxamine with all the links. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). His efforts became more focused on medical research when, in 2007, he was diagnosed with a rare blood cancer. just like ivermectin). I've collected fluvoxamine evidence here for convenient access. February 17, 2021. . Medium revoked my account for life. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. And, according to three members of CETF's scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for . This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog. It has shown to be 100% protective of hospitalization in 2 clinical trials. Fluvoxamine has a 40 year safety track record. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. It could do nothing. this is NOT about the science. @stkirsch. NIH is still unsure whether fluvoxamine should be used to treat COVID. We should not wait for the Phase 3 RCT. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. The External Medicine Podcast - Fluvoxamine as a potential treatment for COVID-19: An Interview with Steve Kirsch. No more. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. But a panel of key opinion leaders from the NIH, CDC . Zero. All the supporting observational studies were positive as well. I bumped up the reward to $1M. If you cant get a prescription for COVID, then perhaps you have OCD? See my article on treatments. Repurposed drugs are safer and more effective than the current vaccines. I mean, he really, truly has a heart of gold, Char told me. It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. 21. Steve Kirsch is looking for an explanation for 171,000 excess deaths. Zero. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Here's why. Who knows, Morris replied. Once the Phase 2 result came out, it should have been embraced by doctors. I disagree with his interpretation of the data regarding several medicines and strongly disagree with his anti-vaccine nonsense, Boulware wrote to me. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. One of the drugs, Fluvoxamine, showed a 30 . In-patient use. And that is what has allowed Kirsch, and people like him, to become so influential. That way you can start immediately. Last Checked: 03/03/2023. P-value was 10^-14 on that study (done by Dr. There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. In other cases, stop cold turkey. , or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). You will be wired for 24 hours if you dont heed my advice. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. So much for evidence-based medicine. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing).
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